Explainable AI for Protein Engineering

Design Better Proteins. Understand Why.

Bridge the gap between computational predictions and lab reality. Combine AI-powered variant design with developability screening and transparent, physics-grounded explanations.

0.82
Avg. ΔΔG R² Correlation
76%
Lab Validation Success Rate
Faster Than Traditional Screening

From Sequence to Validated Variant

A complete workflow that accounts for binding affinity AND real-world manufacturability.

AI Variant Predictions

Ranked mutation recommendations with ΔΔG binding affinity, developability scores, and expression success rates from fine-tuned AlphaFold/ESM models.

3D Structure Visualization

Interactive molecular viewer with constraint editing. Click residues to set disulfide bonds, hydrogen bond distances, and surface charge constraints.

Developability Dashboard

Comprehensive screening for aggregation propensity, isoelectric point, surface hydrophobicity, thermal stability, and host-specific expression warnings.

Explainable Predictions

Understand WHY mutations work through energy contribution maps, new hydrogen bond visualizations, steric clash analysis, and before/after 3D comparisons.

Team Collaboration

Shared project workspaces with commenting, peer review workflows, experimental outcome logging, and wet-lab validation tracking.

Host-Specific Optimization

Automatic codon optimization for E. coli and CHO cells, glycosylation site warnings, signal peptide recommendations, and one-click sequence export.

How ProteinForge Works

Three steps from sequence to validated therapeutic candidate.

1

Upload & Configure

Upload FASTA sequences or PDB structures. Specify your target protein, expression host, and set physical constraints on residues.

2

AI Analysis

Our AI engine analyzes mutations for binding affinity, developability, and expression viability — then explains every recommendation.

3

Validate & Track

Take confident go/no-go decisions. Log experimental results and build a validated track record of prediction accuracy.

Data-First Interface

Every metric at a glance. No black boxes — just transparent, actionable predictions.

proteinforge.ai/dashboard
Active Predictions
24
↑ 18% vs last week
Avg. ΔΔG Accuracy
0.82
R² correlation
Lab Success Rate
76%
+12% improvement
Recent Variant Predictions
mAb-2847_V3
CDR-H3 optimization · E. coli
ΔΔG: -2.4 kcal/mol
Developability: 8.2/10
EGFR-inhib_12A
Stability screen · CHO cells
ΔΔG: -1.8 kcal/mol
Ready for validation
IL6R-binder_7C
Affinity maturation · CHO cells
ΔΔG: -3.1 kcal/mol
Developability: 9.0/10

Stop Guessing. Start Engineering.

Reduce experimental failure rates and accelerate your drug discovery pipeline with transparent, physics-grounded AI predictions.